Dr George Estienne Neuhoff graduated from the University of Pretoria with an MBChB in 1994. He went on to receive a Diploma in Anaesthesia in 1998, followed by a Fellowship of the College of Anaesthetics in 2002 from the University of the Witwatersrand.

His career in chronic pain management started in 2017, and he obtained his Chronic Pain Fellowship from the Pain School International in Budapest. He went on to obtain his Fellowship of Interventional Pain Practice in 2022 with the World Institute of Pain (WIP). Dr Neuhoff is currently on the executive committee as the secretary of the WIP Africa section.